New Standard of Care for Refractory Metastatic Colorectal Cancer Significant improvement in OS, PFS with addition of bevacizumab to trifluridine/tipiracil Jan 23, 2023
What Caused a Man to Develop Friable Bleeding Nodules on His Arms and Hips? The cause lies in a lengthy history of cancer treatment, confirmed by histopathology analysis Jan 23, 2023
'More Is Not Better' in Two First-Line Trials for Biliary Tract Cancer No survival benefit with three-drug chemo regimen or clear PFS gain with anti-PD-L1/bevacizumab Jan 22, 2023
New First-Line Standard for Metastatic Pancreatic Cancer Liposomal irinotecan regimen boosts outcomes, although expert expressed concern about toxicity Jan 22, 2023
Adding Targeted Drug to Chemo Boosts Survival in Gastric/GEJ Cancer Longest overall survival reported to date with the addition of zolbetuximab to chemotherapy Jan 21, 2023
We're Underutilizing Genetic Testing for Colorectal Cancer Universal germline testing should be part of the standard of cancer care Jan 20, 2023
Perioperative Chemo Matches Multimodal Tx for Locally Advanced Esophageal/GEJ Cancer Nearly identical 3-year survival, questioning the need for radiotherapy before surgery Jan 20, 2023
Circulating Tumor DNA Could Guide Use of Chemo in Colorectal Cancer Identified patients likely to benefit following surgery, large prospective study showed Jan 19, 2023
Short-Course Apalutamide to Reduce Active Surveillance Attrition in Prostate Cancer Editorialists question whether any intervention violates principles of surveillance Jan 17, 2023
Epstein-Barr Virus Tracking After Liver Transplant May Cut Rare Complication Observational study provides suggestive evidence Jan 17, 2023
The Unfulfilled Promise of Cannabis for Cancer-Related Symptoms Medical cannabis is currently too far removed from the standards of medical practice Jan 14, 2023
For People With HIV, Early Anal Cancer Screening Tied to Better Outcomes All people with HIV should be screened, not just men who have sex with men, researchers say Jan 13, 2023
Off-the-Shelf T-Cell Therapy Effective Against Viral Infections After Allo-HCT Produced an antiviral response in 95% of patients with six different types of infection Jan 13, 2023
MRI-Guided Focused Ultrasound Eases Pain From Bone Metastases More responses with ultrasound, but quality-of-life scores lower vs EBRT in nonrandomized trial Jan 11, 2023
Study Supports Routine Omentectomy in Absence of Metastasis During CRS-HIPEC High rate of occult metastases in patients with grossly normal omentum Jan 11, 2023
Bariatric Surgery May Reduce Risk of Esophageal, Gastric Cancers Cohort study provides "reassurance of the protective clinical benefits of weight loss surgery" Jan 11, 2023
Zanubrutinib Shows Good Tolerance in BTK-Inhibitor Intolerant Malignancies Most patients had no recurrence of their original intolerance event Jan 10, 2023
Post-HSCT Brentuximab Vedotin Plus Nivolumab Highly Effective in Hodgkin Lymphoma However, toxic effects might limit the combination to the highest-risk patients Jan 10, 2023
Conspiracy Theorists' Cancer Beliefs; HIV Meds and Ethnicity Also in TTHealthWatch: sodium levels and health outcomes Jan 07, 2023 podcast
Genomic Assay May Pinpoint Who Can Skip RT After Breast-Conserving Surgery Patients categorized as low risk with 16-gene signature showed no significant benefit with RT Jan 06, 2023
More Evidence to Support Restrictive Opioid Prescribing After Cancer Surgery Significant decreases in prescription days, doses, refill requests, with few patient complaints Jan 06, 2023
Optimizing Treatment for Older Patients With HR+ Low-Risk Breast Cancer Five days of radiotherapy, five years of hormonal therapy, or somewhere in between? Jan 05, 2023
More Extensive Resection of Low-Grade Glioma Linked to Longer Survival Across both subtypes, improved survival seen with at least 75% resection, study finds Jan 05, 2023
Watch for New Psych Disorders in the Spouses of Cancer Patients Risk especially high within the first year after cancer diagnosis Jan 05, 2023
Jazz Musician With Slowly Expanding Neck Mass Causing Dysphagia Alcoholism, liver dysfunction highly linked with rare disease of unknown etiology Jan 04, 2023
Can Dying Well Be a Part of Living Well? Shoshana Ungerleider, MD, on her mission to transform end-of-life care Jan 03, 2023 podcast
Crystal Ball Cloudy for PI3K Inhibitors' Future in Hematology After a year of negative news, some caution about throwing out the baby with the bath water Jan 02, 2023
Adagrasib Shows Anti-Tumor Activity in Heavily Pretreated KRAS-Mutant CRC Response rates of 19% alone, 46% with cetuximab in phase I/II trial Dec 21, 2022
Early Win for Gene Therapy in Rare Form of SCID 10 infants were able to make their own T cells; safety good so far Dec 21, 2022
Mixed Results With Hormonal Strategies for Premenopausal Breast Cancer Exemestane reduced recurrence, metastasis versus tamoxifen, but no survival benefit Dec 20, 2022
Long-Term Data Reinforce Targeted Combo Versus Single Agent for Advanced Melanoma Encorafenib-binimetinib tops vemurafenib, but checkpoint inhibitors remain first-line choice Dec 19, 2022
OS Benefit Eludes Second-Line Niraparib Maintenance in Ovarian Cancer Significant PFS results demonstrated in NORA trial don't extend to overall survival Dec 17, 2022
FDA Approves First Gene Therapy for Non-Muscle-Invasive Bladder Cancer Half of patients achieved complete responses with adenoviral vector-based product Dec 16, 2022
Anti-PD-1 Drugs Impress as Frontline Therapy for Early, Unfavorable Hodgkin's 3-year PFS of 99%, OS of 100% with nivolumab-chemo, high response rate with pembrolizumab Dec 16, 2022
No Blaming Common Antihypertensives for Pancreatic Cancer, Study Suggests Some reassurance on widely prescribed dihydropyridine calcium channel blockers Dec 15, 2022
New Regimen for GvHD Prophylaxis in Well-Matched Reduced-Intensity Allo-HCT Post-transplant cyclophosphamide, tacrolimus, and MMF reduces GvHD without higher relapse risk Dec 14, 2022
'Practice-Changing' Results With Zanubrutinib Versus Ibrutinib in CLL/SLL Significantly longer PFS with second-gen BTK inhibitor in relapsed/refractory disease Dec 14, 2022
C3 Pathway Inhibitor May Change Practice for Paroxysmal Nocturnal Hemoglobinuria Iptacopan improved hemoglobin without transfusion versus current standard of care Dec 14, 2022
High-Dose Chemo, ASCT Improves Survival in Primary CNS Lymphoma European trial is "practice-changing as of today," says U.S. expert Dec 13, 2022
Prolonged Responses in DLBCL Spark Talk of a Cure With Bispecific Antibody Most complete responses lasted 24 months or longer after limited-duration glofitamab Dec 13, 2022
