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Endocrinology

News, opinions and meeting coverage in endocrinology.

Finger Stick Has Promise as Prediabetes Test

PHOENIX -- Measuring capillary blood via finger stick assay was as accurate as venous blood sample assays in predicting 5-year likelihood of diabetes, researchers reported here.

Case Study Links 'Pot' to Pituitary Damage

PHOENIX -- Daily use of marijuana over 15 years was associated with a case of low testosterone, follicle-stimulating hormone, and luteinizing hormone, researchers reported here.

How Much Exercise to Burn Off a Burger?

Menus displaying the amount of exercise required to burn off calories in a meal had some impact on food choice, researchers found.

Full Thyroid Removal May be Best in Graves' Disease

Removing the whole thyroid lessens the chance of hyperthyroidism recurrence in Graves' disease compared with partial thyroidectomy, but it also leads to increased temporary hypoparathyroidism, researchers found.

FDA Splits on Safety of Endo's Aveed for Low-T

SILVER SPRING, Md. -- An FDA advisory committee was split Thursday on the safety of an injectable form of testosterone replacement, but voted overwhelmingly against a proposed risk mitigation plan.

C. Diff Dangerous in ESRD

ORLANDO -- Kidney dialysis patients who are infected with Clostridium difficile have a greater risk of infection relapse and also have a higher all-cause mortality that patients who do not have kidney disease, researchers said here.

Cardio Notes: Sex Improves with Stenting

Opening the arteries of those with stable coronary disease also opens the door to an improved sex life. Also this week, bariatric surgery helps remodel the heart.

Study Counters WHI on Risk of Hormones in Menopause

Hormone therapy may actually help the heart in some respects for newly menopausal women, a randomized trial showed, although the impact on hard outcomes like stroke and breast cancer still remains to be seen.

Weight Gain After Bypass Not Affected by Diet

SAN ANTONIO -- Lifestyle factors -- including dietary intake, physical activity levels, and treadmill time -- were not predictive of weight regain from 2 to 6 years after Roux-en-Y gastric bypass, researchers found.

Genetic Obesity Risk Heightened by Sugary Drinks

SAN ANTONIO -- The relationship between genetics, body mass index, and obesity risk appears to be magnified in adults who drink the most sugar-sweetened beverages, researchers found.

Low Preop Sodium Raises Mortality Risk

Preoperative hyponatremia significantly increased the risk of 30-day postsurgical mortality, a risk that extended across all subgroups of surgical patients, investigators reported.

Playing Sports Helps Teens Fight Fat

Team sports may fight weight problems better than other forms of exercise among high schoolers, researchers found.

NAMS Founder: WHI Wrong on HRT

A leader of the North American Menopause Society wants an independent review of all major publications from the Women's Health Initiative.

No Weight Gain with Linagliptin in Diabetes

The DPP-4 inhibitor linagliptin may control type 2 diabetes with less hypoglycemia or weight gain than glimepiride when used as second-line treatment with metformin, a trial showed.

Vitamin D Test Accuracy Called into Question

HOUSTON -- Two widely used tests to determine vitamin D status produced results that exceeded the allowable limits for error in at least 40% of cases, according to a study reported here.

Big Breakfast, Plus Dessert Aids Weight Loss

HOUSTON -- Obese adults lost significantly more weight by starting the day with a calorie-and carbohydrate-heavy breakfast that included a sweet treat, instead of saving more calories for dinner, according to a study reported here.

Testosterone Tx Helps Obese Men Trim Waistline

HOUSTON -- Obese hypogonadal men lost an average of 36 pounds during long-term testosterone replacement therapy, results of a prospective cohort study showed.

Lymphedema Tied to Obesity

Obesity may contribute to the development of lymphedema, a small study showed.

Tattoos Replace Bracelets for Medical Alerts

PHILADELPHIA -- As more people with diabetes replace their medical alert bracelets with tattooed warnings, there might be a need for a standard design and body location, a researcher here said.

Prolia Linked to Serious Skin Side Effects

RALEIGH, N.C. -- More than 40 serious cutaneous adverse events linked to the osteoporosis formulation of denosumab (Prolia) were discovered in a review of FDA records, investigators reported here.

DSM-5: What's In, What's Out

PHILADELPHIA -- Reports here provided what may be the last public update on DSM-5, the next edition of American psychiatry's diagnostic guide, before it is formally released in May 2013.

OTC Bug Bite Remedies of Little Help

Treating simple bug bites isn't usually necessary and there's little evidence to support doing so, a review warned.

Doctors Say 45 Common Tests 'Overused'

Nine specialty groups have listed tests and treatments that are frequently overused, such as antibiotics for sinus attacks and CT scans for low back pain, in the first phase of a long-term project.

FDA Adds More Warnings for Lipitor, Crestor, and Zocor

WASHINGTON -- Statins may cause drug-drug interactions for patients taking drugs to treat HIV/AIDS or hepatitis C, according to a new statin warning from the FDA.

FDA Adds Diabetes Warning to Statin Label

WASHINGTON -- The FDA is changing the labeling on statins to include a warning about increased risks of hyperglycemia and transient memory problems, but the agency is no longer recommending routine liver function testing.

Diabetes Expert Disses Weight-Loss Programs

WASHINGTON -- Community-based weight-loss programs have not been shown to be effective at reducing the incidence of diabetes, so implementing a national program would likely be money down the drain, a diabetes expert said at a symposium on Tuesday.

Fructose No Substitute for Glucose in Diabetes

NEW YORK -- Although it negates the dumping of glucose directly into the bloodstream, fructose may not be the choice sweetener for diabetics, researchers said here.

RSNA: Growth Hormone May Help Heavy Women With Bone Problems

CHICAGO -- Premenopausal women who are obese may not be spared from osteopenia, as some research has suggested, but growth hormone therapy may help spur bone formation, researchers said here.

Readers Say Vitamin Levels Should Be Checked Yearly

Processed foods, mineral-depleted soil, overcooked vegetables, increased stress levels -- all of these increase the chances of having a vitamin deficiency, according to a vocal majority of 番茄社区 readers who commented on last week's poll.

EASD: Gestational Diabetes Guidelines Controversial

LISBON -- International guidelines on screening for gestational diabetes that will likely raise the prevalence of the condition have sparked questions over appropriate diagnostic tools and cost efficacy, researchers said here.

Cancer Risk Forces Actos Off French, German Markets

Drug regulators in Germany and France have ordered doctors to stop prescribing the type 2 diabetes drug pioglitazone (Actos), following a French study suggesting a heightened risk of bladder cancer.

IUD Safe Right After Abortion

Women undergoing an abortion can have an intrauterine device (IUD) safely placed immediately after the procedure, with similar rates of expulsions and other complications, a randomized trial found.

ASCO: Flaxseed No Help for Hot Flashes

CHICAGO -- Flaxseed will not ease hot flashes for women with menopausal symptoms or breast cancer survivors taking anti-estrogen drugs, according to clinical trial results.

15 Eggs Magic Number for Best Results in IVF

The odds of achieving a live birth after in vitro fertilization (IVF) increased steadily with the number of eggs retrieved after ovarian stimulation, topping out at about 15, data from a large IVF registry showed.

SID: No Skin Cancer Risk Seen With Prednisone

PHOENIX -- Use of systemic corticosteroids did not increase the risk of nonmelanoma skin cancer in a prospective study, contradicting previous evidence from several retrospective studies, investigators reported here.

Diet, Exercise Sufficient to Reduce Triglycerides

While cholesterol control is often balanced between statins and lifestyle changes, reducing triglycerides can usually be accomplished with diet and lifestyle changes alone, according to a new scientific statement from the American Heart Association.

FDA Approves Testosterone Gel Applied to Thigh

A topical testosterone gel designed to be applied to the upper leg has won FDA approval for use by testosterone-deficient men, its manufacturer said.

Take Rosiglitazone Off the Market, Says FDA Staff

WASHINGTON -- Rosiglitazone (Avandia) should be pulled from the market because of the "serious" cardiovascular risk the diabetes drug poses, which exceeds that of competitor pioglitazone (Actos), FDA staff reviewers again recommended.

ACC: Triglycerides Decreased with Rosuvastatin Therapy

ATLANTA -- In a study that specifically scrutinized the effects of statin therapy on triglycerides, researchers said that rosuvastatin (Crestor) significantly reduced the blood lipid that has been linked to coronary artery disease better than placebo.

ACC: FDA Announces Review of ACCORD Data

ATLANTA -- The FDA said it will conduct a full review of findings from a study which concluded that neither aggressive lipid-lowering therapy nor tight blood pressure control reduced cardiovascular events in persons with diabetes.

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