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General Rheumatology

News, opinions and meeting coverage in rheumatology.

A photo of a man鈥檚 hand with psoriatic arthritis over the packaging of Tremfya

Two Years On, Tremfya Still Shines in Psoriatic Arthritis

Efficacy increases in long-term extension data

A close up of a senior grandmother grasping her granddaughters hands

Mystery: Why Would Hand OA Be Less Severe in Black People?

Data contrast with previous findings for hip and knee osteoarthritis

A bottle of Xeljanz tablets over yellow caution tape forming an X

Trial Data Confirm Heightened Risks With JAK Inhibitor

May help patients and clinicians better weigh benefit against adverse effects

A close up of a senior woman鈥檚 arthritic hand resting on a cane.

How Preventable Is Rheumatoid Arthritis?

Big study sets a number

A close up of a woman pushing a statin pill out of a blisterpack

Psoriasis Patients, Docs Want to Do More to Prevent Heart Problems

Despite well-known cardiovascular risks, most patients currently undertreated

A photo of vasculitis rash on a woman鈥檚 legs

Don't Expect Much From COVID Vax in This Patient Group

With rituximab on board, even third doses didn't induce meaningful antibody response

The packaging and blister pack of Cymbalta

Muddled Picture for Antidepressant as Osteoarthritis Pain Reliever

Trial in primary care setting fails to confirm benefit seen in specialty clinics

A box of Cosentyx 150 mg solution for injection in two pre-filled pens

Biologic Disappoints for Arthritis Achilles' Inflammation

But phase III trial did find some patient-oriented benefits

ACR over a photo of the Moscone Center in San Francisco, CA.

For Systemic JIA, Start Biologics Early

Observational study shows excellent efficacy in systemic pediatric arthritis

ACAAI over a photo of the Ernest N. Morial Convention Center in New Orleans, LA.

HAE Still Drawing Attention From Drugmakers

Two new products show midstage promise in hereditary angioedema

ACR over a photo of the Moscone Center in San Francisco, CA.

Secukinumab: An Up-and-Coming Option in Giant Cell Arteritis?

Phase II trial found sustained remission with steroid-sparing effects

ASN over a computer rendering of a transparent torso with the kidneys highlighted in black.

Avacopan Helps Vasculitis Patients With Renal Impairment Wean Off Steroids

Patients saw better eGFR recovery compared with prednisone

ACR over a photo of the Moscone Center in San Francisco, CA.

Vitamin D and Disease Prevention: Worth Another Look?

Incidence of autoimmune disease decreased by 25-30% with dietary supplements

ACR over a photo of the Moscone Center in San Francisco, CA.

Guselkumab Response Durable in Psoriatic Arthritis

Skin and joint improvements persisted through 2 years of follow-up

ACAAI over a photo of the Ernest N. Morial Convention Center in New Orleans, LA.

Could This Biologic Drug Work in Patients Lacking Its Target?

Bizarre finding with omalizumab

A computer rendering of two monoclonal antibodies of differing coloration over an inflamed bronchial tube.

Mixed Results With Anti-Interleukin Biologics in Asthma

One shows promise; another fails miserably (and mysteriously)

A computer rendering of ankle osteoarthritis

No Love for PRP in Ankle Osteoarthritis Trial

Dutch researchers throw cold water on popular therapy

The packaging and vials of Benlysta (belimumab)

Following Rituximab With Second Biologic Helpful in Lupus

Trial may provide answer for patients who don't respond to B-cell depletion

A close up of a man scratching the psoriasis on the back of his hand

How Should Patients With Autoimmune Diseases Approach COVID Vaccination?

Mixed messaging and a lack of tailored research leaves providers and patients in the dark

FDA APPROVED adalimumab-adbm (Cyltezo) over a photo of a woman using an auto injector syringe.

First Interchangeable Humira Biosimilar Approved

Cyltezo nabs coveted "interchangeable" status for RA, inflammatory bowel disease, and more

FDA APPROVED avacopan (Tavneos) over a photo of a man鈥檚 foot showing vasculitis.

FDA Gives Thumbs Up to ANCA-Associated Vasculitis Drug

Approval granted to avacopan despite advisory committee concerns

ASBMR over a computer rendering of a human skeleton

Is This the Future of Corticosteroids?

Novel agent, aimed at doing away with adverse metabolic effects, proves mettle in DMD

A photo of a woman attempting to smell half of an orange.

Olfactory Loss Common in Sjogren's Syndrome

Objective impairments in olfaction correlated with disease activity and symptoms

A young boy curled up on the sofa with stomach pain.

IBD and Pediatric Arthritis: Exploring the Link

Risk factors include enthesitis, family history, and etanercept use

A micrograph of pneumocystis (carinii) jiroveci

Pneumocystis Often Lethal in Dermatomyositis

Incidence of pneumonia high in MDA5-antibody-positive patients

An image of of package of Xeljanz

FDA Slaps Restrictions on JAK Inhibitors Over Serious Safety Risks

Use for inflammatory conditions limited to those who fail on TNF blockers

Photo of 72-year-old woman being evaluated for mild pain and joint stiffness in her hand.

What's Causing Cancer Patient's Joint Pain While on Checkpoint Inhibitor?

Here is how clinicians diagnosed this rare inflammatory side effect

A woman kisses her elderly mother on the forehead in the kitchen.

What Factors Predict RA in First-Degree Relatives?

Study may offer insight into preclinical phase to identify factors that predict progression

A bottle and tablet of Rinvoq (Upadacitinib) over a close up of a man scratching the eczema on the back of his hand

JAK Inhibitor Tops Mab for Eczema

New disease-modifying treatment option on the horizon

A mature man laying on a couch winces from abdominal pain.

New-Onset IBD and IL-17 Inhibitors: What Is the Risk?

Underlying inflammatory disease severity should be taken into account

FDA APPROVED immunoglobulins (IVIG; Octagam 10%) over photos of adults with dermatomyositis

FDA Approves IVIG for Dermatomyositis

Octagam 10% lands indication for adults following results of ProDERM trial

An empty prescription bottle laying on its side.

Slow Steroid Tapering Succeeds in SLE

Flare rates were significantly lower with gradual withdrawal than with low-dose maintenance

A close up of a Heartmate 3 left ventricular assist device

Skin Rash Should Be a Huge Red Flag for LVAD Recipients, Group Says

New phenomenon suggests perils of not performing biopsy in time

A senior woman massages her painful arthritic hand

Pain Persists in RA, Even Without Inflammation

At 5 years, one-third of patients with rheumatoid arthritis still had "unacceptable" pain

A senior Asian woman sits on her couch experiencing knee pain.

Osteoarthritis: A Link With Parkinson's?

Inflammation may contribute to both joint and nerve degeneration

EULAR over a computer rendering of human body parts with the major joints glowing red

Secukinumab Shows Promise for Kids With Arthritis

More than 90% responded at week 12, study showed

EULAR over a computer rendering of human body parts with the major joints glowing red

Personalized Algorithm Helps Guide Rituximab Retreatment

For ANCA-associated vasculitis, fixed retreatment not needed if naive B cells reappear

EULAR over a computer rendering of human body parts with the major joints glowing red

IVIG a Winner for Dermatomyositis

Pivotal phase III trial shows clear efficacy

EULAR over a computer rendering of human body parts with the major joints glowing red

Nintedanib Slows Decline in RA-Associated Interstitial Lung Disease

Similar results to original larger trial seen in post-hoc analysis

EULAR over a computer rendering of human body parts with the major joints glowing red

Oral JAK 1 Inhibitor Eases Spine Inflammation in Ankylosing Spondylitis

Treatment with filgotinib resulted in significant improvements compared with placebo

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