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Compared with lurasidone (Latuda), the investigational oral antidepressant NRX-101 did not significantly reduce suicidality in and missed statistical significance in reducing symptoms of akathisia in a phase IIb/III trial, said developer NRx Pharmaceuticals.

Meanwhile, met its primary endpoint as an adjunctive treatment in a phase II/III study of people with chronic schizophrenia who did not adequately respond to second-generation antipsychotics, Newron Pharmaceuticals announced.

A small trial of people with bipolar mania suggested response rates with were comparable to those with modified electroconvulsive therapy with fewer effects on language ability. (JAMA Network Open)

About 75% of Americans said they felt were identified and treated much worse than physical health issues in the U.S. healthcare system, according to a West Health and Gallup survey.

The FDA approved Amneal Pharmaceuticals' generic for emergency treatment of an opioid overdose.

Veterans Crisis Line caring letters but were associated with a boost in outpatient and inpatient mental health care use among veterans. (JAMA Network Open)

Children and adolescents in had lower cumulative incidences of anxiety disorders, depressive disorders, and attention-deficit/hyperactivity disorder, a study in Taiwan showed. (JAMA Pediatrics)

The risk of -- a life-threatening adverse event -- sharply dropped over time, but might be persistently higher in clozapine versus non-clozapine antipsychotics, a study of people with schizophrenia or schizoaffective disorder in Finland found. (Lancet Psychiatry)

rose in all age groups and in all states since 2019, a FAIR Health analysis of private healthcare claims reported.

Loneliness followed a : it was higher in younger and older adulthood, and lowest during middle adulthood, according to an analysis of nine studies. (Psychological Sciences)

Compared with premenopausal women, had a 40% higher risk for depressive symptoms and diagnoses, which fell after menopause, a meta-analysis showed. (Journal of Affective Disorders)

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