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News, opinions and meeting coverage in primary care.

A vial of ocrelizumab (Ocrevus) next to an MRI image of progressive multifocal leukoencephalopathy (PML)

PML Reported in Ocrelizumab-Treated MS Patient

Case raises questions about treatments for older people with multiple sclerosis

A pile of yellow gel capsules

Skip These Supplements for Afib Prevention

Long-term results from the VITAL Rhythm study in a large population

An African-American male wearing an oxygen mask lies in a hospital bed

Uneven Progress Closing Race Gap in Heart Health

Urban areas more successful at narrowing disparities

A computer rendering of a coagulated clot of red blood cells entangled in fibrin

Op-Ed: COVID Shot While on a Blood Thinner?

One hematologist's strategy for addressing concerns

A woman鈥檚 hand holds a swab and specimen container from a COVID-19 Home Test kit on her lap

Pathologists Urge Caution on At-Home COVID Test Kits

"Did it sit in the sun?"

Photo of Iora Health co-founder Rushika Fernandopulle, MD (Photo courtesy Iora Health)

Healthcare Disruptors: Doubling Down on Primary Care

Iora Health and its care teams are changing the way primary care is delivered

When Can I Walk Into a Pharmacy and Get a COVID Shot?

Walgreens' Rina Shah, PharmD, on the challenges and opportunities

A senior woman in front of her open medicine cabinet using a pill organizer

Dementia Patients Often Have Dangerous Mix of Drugs at Home

Combinations increase risk of falls, respiratory suppression, cognitive impairment

An ECG of a heartbeat over a close up of a man clutching his chest

Universal Definition of Heart Failure Proposed

U.S., European, and Japanese societies seek to standardize classifications

Apples, grapefruit, oranges, pears, kiwi, lemons, and limes line the shelves at a grocery store.

And the Magic Number for Daily Fruit, Vegetable Intake Is...

No benefit to peas, corn, potatoes observed in cohort studies

A close up of a senior man and woman embracing, her hand on his cheek

Ethics Consult: Does Dementia Preclude 'Consent' to Sex? MD/JD Weighs In

You voted, now see the results and an expert's discussion

AAN over several MRI scans of a brain

Alzheimer's May Start Sooner for People With Anxiety, Depression History

Psychiatric disorders could have additive effects on AD pathophysiology, study suggests

A photo of the Zio XT wearable ECG patch

ECG Patch Boosts Afib Diagnoses in Older Folks

But unclear if it's clinically beneficial

The packaging and syringe of Kineret (anakinra) over a microscope image of uric acid crystals

Anakinra for Gout Flares: Is There a Role?

IL-1 blockade was not superior to triamcinolone, but does have advantages

The vials and packaging of Opdivo (nivolumab) and Yervoy (ipilimumab) for injection

Neoadjuvant Dual ICI Leads to Clinical Benefit in Operable NSCLC

More than one-third of patients achieved major pathologic response with nivolumab-ipilimumab.

Can the Same Vaccines Protect Against New COVID Strains?

Questions about long-term efficacy become more insistent

FDA APPROVED Sacubitril/valsartan (Entresto) over a photo of a man clutching his chest which is highlighted in red

First Drug Approved for Some HFpEF

FDA doesn't set hard limits on ejection fraction in expanded indication

Brain scan images with NeuroBreak in the center.

Sleep-Dementia Link; Neanderthal Mini-Brains; MS Tx and COVID Vax

News and commentary from the world of neurology and neuroscience

GuCS over a computer rendering of the genitourinary system

CCR Score Could Offer ADT-Free Path in Higher-Risk Prostate Cancer

Large proportion of intermediate- to high-risk patients could avoid aggressive therapy

GuCS over a computer rendering of the genitourinary system

Radionuclide Tx Wins in Third-Line Metastatic CRPC

Early trial shows improved PFS, response rates versus cabazitaxel

GuCS over a computer rendering of the genitourinary system

Hit and Miss in Castration-Resistant Prostate Cancer

No OS benefit with apalutamide-abiraterone, despite improved PFS

A photo of the top of a balding man鈥檚 head showing actinic keratosis

Want Data on Recently Approved Actinic Keratosis Drug? Here You Go

Phase III trial now published in full for topical anti-proliferative treatment

A senior woman uses the shoulder press machine at the gym

HIIT for HFpEF? Results Mixed in Exercise Trial

Boosting intensity not obviously helpful

A man wearing work gloves holds 5 pieces of clogged metal pipe

Coronary Disease: Plugged Pipes or Popped Pimple?

A better analogy for what's happening to the coronary vessels

Looking over the shoulder of a senior man having dinner on a TV tray

Nutrition Status Tied to TAVR Outcomes

Data support pre- and post-TAVR dietary interventions for the elderly

A computer rendering of an HDL particle

HDL Cholesterol Linked to Parkinson's Disease

Population study shows relationships between HDL levels and variability with incident PD

A computer rendering of white pills forming a $ sign. There is a human figure at one end of the $ and a heart at the other.

Why No Price Competition in Brand-Name Heart Drugs?

The Skeptical Cardiologist raises an eyebrow at the DOACs

A man receives external beam radiotherapy

Whole-Pelvis Tops Prostate-Only RT in High-Risk Disease

Practice impact may hinge on knowledge versus clinical bias

An MRI of the brain showing perivascular spaces

Dementia Tied to Large Perivascular Spaces

Enlarged spaces around cerebral small blood vessels linked to cognitive decline over time

A smiling woman who has just turned 100 points at her head

High Cognitive Performance at Age 100

Some centenarians show resilience to cognitive decline, despite brain pathology

A computer rendering of a stent opening a clogged artery and allowing blood to pass

In STEMI PCI, Symptom-to-Balloon Time Is What Counts

Study authors urge greater efforts to reduce pre-hospital delays

A computer rendering of oropharyngeal cancer

Nuanced View of Oral Sex, HPV+ Oropharyngeal Cancer

Age at first oral sex, 'intensity,' number of partners all influence risk

An illustration of a person's thoughts and memories connected to their brain

Primary Progressive Aphasia in Alzheimer's Doesn't Foretell Memory Loss

No memory decline over more than 2 years in small study, though speech deficits grew

An illustration of dice over a Gleason鈥檚 pattern score graphic

Is This Really Cancer?

Movement builds to classify Gleason 6 prostate lesions as nonmalignant

A box of Tagrisso (osimertinib) tablets and a vial of Avastin (bevacizumab)

Targeted Combo Fails in EGFR-Mutant NSCLC

Osimertinib-bevacizumab no better than osimertinib alone

A blue rubber gloved hand holds a vial of blood labeled Alzheimer - Test

Alzheimer's Blood Tests: Big Breakthroughs in 2020

Game-changing strides in tau assays, and an amyloid test enters the market

A photo of Ralph Dotinga on a stack of old photos next to lilies

The Long Goodbye: How COVID Took My Dad's Life

A single-word text from Room 993 - 'help' - and a grim cascade of complications

A box and blister pack of Gabapentin 600mg tablets

Gabapentinoids Plus Opioids Up Overdose Risk After Surgery

Absolute risks of adverse events were low, however

A female neurologist places electrodes on her senior male patients head

Rising Out-of-Pocket Costs for Neurology Visits, Diagnostic Tests

Neurologist distribution varies widely, as does involvement in patient care

How Do We Inject Confidence Into Vaccine Hesitant Americans?

"We need to really up our game in terms of communicating," says Peter Hotez, MD, PhD

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