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News, opinions and meeting coverage in primary care.

A bottle of Nuplazid (pimavanserin) capsules over a photo of a senior woman hiding her eyes with her hands.

Parkinson's Drug Tied to Increased Hospitalizations, Death

Mortality risk persisted in people taking pimavanserin

Retinal imaging of nonproliferative diabetic retinopathy

Anti-VEGF Injections Preserved Vision in Severe Diabetic Retinopathy

Aflibercept also reduced vision-threatening complications

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Driving Patterns Pinpoint Early Alzheimer's Disease

Subtle shifts in on-road behavior suggest GPS-based biomarkers may have merit

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

COVID-19: Persistent Cognitive Effects, Uptick in Alzheimer's Biomarkers

Findings link cognitive impairment and long-lasting anosmia

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Aducanumab: What to Know If You Prescribe

Recommendations may change when trial data are published

AAIC over a computer rendering of phosphorylation of tau proteins leading to disintegration of microtubuli in a neuron axon

Better Air, Better Brains

Reducing air pollution tied to lower dementia risk, slower cognitive decline

Illustration of a brain shaped maze.

Drug Overdoses Spike; Shock Therapy Effective; Psychiatrist Charged for 'Pill-Mill'

News and commentary from the psychiatry world

A stressed looking senior woman next to a bottle of Nuplazid (pimavanserin) capsules.

Staying on Pimavanserin Cut Dementia-Related Psychosis Relapse

However, late-stage trial couldn't separate efficacy in dementia subtypes

A mature man laying on a couch winces from abdominal pain.

New-Onset IBD and IL-17 Inhibitors: What Is the Risk?

Underlying inflammatory disease severity should be taken into account

A senior woman talks on her smartphone at home.

Phone Calls Spot Early Alzheimer's

Predictive model identified vocal features of dementia patients from everyday speech

FDA ADCOMM roxadustat over a computer renering of chronic kidney disease.

Safety Concerns Turn FDA Panel Thumbs Down for Novel CKD-Anemia Drug

Advisory committee rejected oral anemia drug for dialysis and non-dialysis patient populations

The vial and packaging of Aduhelm (aducanumab) for injection with blurred prescribing information in the background.

Alzheimer's Aducanumab Prescribing Information Changes

"We as neurologists need a strategy to advise our patients," experts say

A chart showing estrogen levels in a female silhouette from age 25-80

Alzheimer's Biomarkers Tied to Endogenous Estrogen Exposure in Women

Longer reproductive period linked to amyloid, p-tau in cognitively normal older women

A screenshot of a TikTok video with Kelly Morris with the caption: I鈥檇 unplug your vent to charge my cell phone.

Nurse Suspended Over TikTok Videos About Patients

Only thing hurt in her posts were "people's feelings," nurse said

A mature person with Down syndrome draws in an activity book.

APOE Gene Influences Alzheimer's Symptoms, Biomarkers in Down Syndrome

Earlier Alzheimer's changes seen in APOE4 carriers

A young female healthcare worker in blue scrubs holding a brochure speaks to a concerned looking senior woman.

Give All Patients a Voice in Their Care

The pandemic has emphasized the importance of access to advance care planning

A computer rendering of the release of cytokines.

Two Inflammatory Proteins Linked With Slower Cognitive Decline

Surprise finding ties plasma cytokine levels with Alzheimer's biomarkers and cognition

A computer rendering of a Trulicity (dulaglutide) auto injector over a photo of a twisted sheet.

'Modest' Erectile Dysfunction Benefit With GLP-1 Agonist

Dulaglutide didn't improve pre-existing symptoms, but did prevent some new cases

A 3 layer pill with ixazomib, lenalidomide, and dexamethasone etched into it over a microscopy of multiple myeloma.

No Survival Benefit With All-Oral Regimen for Relapsed/Refractory Myeloma

Prolonging PFS a positive, as advances make OS improvement harder to achieve

A low angle view of a senior woman holding her bandaged wrist.

Does Grandma Need Surgery for That Broken Wrist?

Randomized trial findings should help in decision-making

EHA over a computer rendering of red blood cells flowing through an artery

Fixed-Duration, All-Oral Regimen Slows CLL Progression

Near-80% reduction in PFS hazard with ibrutinib-venetoclax versus obinutuzumab-chlorambucil

A microscopy of Neurofibrillary tangles in the Hippocampus of an old person with Alzheimer-related pathology.

Alzheimer's Tau Vaccine Shows Immune Response, Safety

Exploratory, post hoc analyses hint at plasma NfL changes, and in some, slower cognitive decline

SLEEP over a conceptual image of dreaming: a woman in a bed floating in the clouds with birds.

Trouble Falling Asleep Predicts Later Cognitive Impairment

Depression and vascular disease may play roles

A senior woman visits with her female gynecologist.

Most Older Women Do Not Meet Criteria to Stop Cervical Cancer Screening

Inadequate screening in middle age, lack of medical record documentation highlighted

A photo of a traditional British breakfast with sausage, fried eggs, ham, toast, beans, a tomato, and mushrooms.

An Unhealthy Diet Feeds Into Clonal Hematopoiesis

Can diet mitigate the CVD risk of this age-related genetic phenomenon?

$An x-ray image of a persons arm with fractured radius and ulna$

Are All Types of Fractures Predictive of Osteoporosis?

Researchers investigate both traumatic, non-traumatic types

A female nurse at a computer workstation reviews a bone mineral density scan of her mature male patient

With Supplements, ADT in Prostate Cancer of Little Threat to Bone Density

Study suggests calcium/vitamin D alone sufficient for long-duration therapy

A lateral x-ray of a mans head with electrodes in place for deep brain stimulation

How Long Do Deep Brain Stimulation Benefits Last?

Parkinson's patients saw continued improvement in motor symptoms, quality of life

A photo collage of a wall clock and a portrait of a senior man staring into space and disintegrating into particles.

Cognitive Clock Predicts Brain Health

Brain age forecasts outcomes better than chronological age

A computer rendering of phosphorylation of tau proteins

Simple Tool Predicts Individual Alzheimer's Risk

Blood and quick cognitive tests boost accuracy to 90%

AACE over a computer rendering of a woman with her pituitary and thyroid glands highlighted.

High Frequency Spinal Stimulation Succeeds in Diabetic Neuropathy

Pain relief was significant and durable in SENZA-PDN trial

AACE over a computer rendering of a woman with her pituitary and thyroid glands highlighted.

Two-Agent Osteoporosis Treatment Boosts BMD

3D DXA images shows separate assessments of trabecular and cortical bone in ACTIVExtend trial

AACE over a computer rendering of a woman with her pituitary and thyroid glands highlighted.

COVID-19 in Diabetes: What Mediates Risk?

Certain clinical factors tied to higher chance of severe infection

A photo of Daniel Gibbs, MD, PhD, next to his book A Tattoo on My Brain

A Neurologist Faces His Alzheimer's Disease

"I'm in the ring with the tiger," says Daniel Gibbs

A blue gloved hand holds a test tube of blood labeled Testosterone - Test over a form with results showing low testosterone.

Low Testosterone Could Be Bad News in COVID-19

In small study, men with low levels were more likely to have severe illness

Breast Cancer Screening During COVID Reveals Inequities

Vinay Prasad, MD, MPH, discusses new findings and his takeaway

ACC over a computer rendering of the human heart and major blood vessels

Renal Denervation Shows Worth in Resistant Hypertension

Catheter-based procedure gets a win in RADIANCE-HTN TRIO

An example of text characters translated from brain signals by an implanted sensor

Implanted Sensor Translates Brain Signals Into Text

Brain-computer interface decodes handwriting movements from neural activity

A young female nurse gives medication to an elderly woman laying in bed

Blood Thinners Continue at End of Life, Despite Risks

No clear guideline for stopping anticoagulants in patients with advanced dementia

A computer rendering of beta-amyloid protein clumping and tau protein accumulating in a brain with Alzheimer鈥檚 disease.

Defining Alzheimer's: Should Cognitively Unimpaired People Be Included?

A definition that works for research is not right for the clinic, experts argue

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