番茄社区

The incidence of late-onset psoriatic arthritis (PsA) occurred more frequently in men, and was associated with worse functionality and more structural damage than individuals with early-onset PsA, according to a study recently presented at the American College of Rheumatology (ACR) annual meeting.

In this video courtesy of , Olga Petryna, MD, of NYU Grossman School of Medicine in New York City, discusses the .

Following is a transcript of her remarks:

Today I would like to share abstract 0377, which is a study from Spain. It's an observational study from two different cohorts of patients with PsA, where authors divided patients into two separate groups: Patients with early-onset PsA, which is onset before the age of 40, and those who were diagnosed after the age of 60 and labeled late-onset PsA.

Researchers looked into the differences in the clinical presentation and outcomes of patients who were diagnosed early versus late-onset disease. And they found that when it comes to clinical presentation, patients who have late-onset disease are more likely to be male; they happen to have more structural damage and worse functional scores by BASFI [Bath Ankylosing Spondylitis Functional Index] at the time of diagnosis, even though there is less diagnostic delay when it comes to establishing diagnosis.

Also, late-onset patients are more likely to have inflammatory arthritis effect in upper extremities, and they were more likely to suffer from comorbidities, particularly higher rate of heart disease was observed in this group.

When it comes to presentations such as sacroiliitis and enthesitis, those are more likely in early-onset disease, and they seemed to not affect quality of life as much in the younger population.

I found it interesting that while the patients with sacroiliitis and enthesitis were seen in a younger population more often, there was no difference in disease activity and severity between the two groups, and it seems that differences in clinical presentation did not affect treatment choice based on the age of onset.

I would be curious to see more studies about treatment choices in patients with disease diagnosing in younger age as opposed to older groups, particularly because we do see there's more structural damage, more impact on quality of life and functional status in these older diagnosed patients. But I guess I'll have to scavenge for more abstracts in that regard.

Comment