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Gastroenterology

News, opinions and meeting coverage in gastroenterology.

A computer rendering of bits of DNA in the blood stream.

Blood Test for CRC Screening Lags Behind Other Options in Cost-Effectiveness Study

Fewer cancers, cancer deaths prevented; higher cost per quality-year saved

A photo of a McDonald鈥檚 Quarter Pounder hamburger and fries.

At Least 75 People Sickened as Deadly McDonald's E. Coli Outbreak Expands

Nearly two dozen people have been hospitalized

A computer rendering of a transparent body with a diseased liver highlighted.

Algorithm May Be Able to Predict HCC Risk in Advanced Chronic Liver Disease

Easy to apply, uses parameters commonly measured in outpatient and inpatient settings

YouTube thumbnail with Siobhan Deshauer, MD, holding a red pepper and the words: SPICY SCIENCE.

Are Spicy Foods Dangerous to Your Organs?

Spicy foods may have health benefits, but they also carry some risk

IDWeek over a photo of the Los Angeles Convention Center in Los Angeles, CA.

Are Norovirus Vaccines on the Horizon?

Two candidates leverage unique technologies

A Look at Food-Related Illnesses at Restaurants Over the Years

While pretty rare for well-known restaurant chains, they do happen

A photo of a fecal immunochemical test lying on a plastic envelope.

How Do Younger People Fare With Stool Tests for CRC Screening?

Retrospective study answers questions raised in shift to screening at age 45

Rainfall and Mortality; Identifying Risk for Preeclampsia

Also in TTHealthWatch: HIV-positive kidney donors

FDA APPROVED FDA has approved zolbetuximab (Vyloy) over a computer rendering of a monoclonal antibody and cancer cells.

Novel Targeted Drug Approved for Stomach Cancers

Zolbetuximab indicated alongside fluoropyrimidine- and platinum-containing chemotherapy

A computer rendering of monoclonal antibodies and ulcerative colitis.

Novel Drug Maintained Clinical Improvements in IBD

Greater benefit seen with higher dose of tulisokibart at week 50

A computer rendering of a transparent body with the large intestine highlighted.

Allele May Heighten Risk of Severe Ulcerative Colitis

Finding on HLA-DRB1*01:03 supports need for more and earlier genetic studies

A computer rendering of a diseased liver in a transparent body.

Novel Drug Effective Against MASH in Phase II Trial

Fatty acid synthase inhibitor targets main drivers of liver injury

A photo of a female doctor writing on a clipboard.

Industry Clinic 鈥� Ad Insights

Why Are Liver Disease Patients Being Left Behind?

The YouTube thumbnail with a cartoon man in scrubs next to a pile of money and the words: Over $500k

Highest Paid Medical 番茄社区 in 2024

Each of these specialties average over $500k per year

A computer rendering of nerve cells.

Some Cancers Occur More Frequently in Multiple Sclerosis Patients

Bladder, brain, and cervical cancer risks were higher in people with MS

A computer rendering of a colorectal polyp.

Colorectal Cancer Screening Uptake Tripled in 45-49 Age Group

Rates rose after USPSTF recommendation, but increase was uneven

The YouTube thumbnail with Siobhan Deshauer, MD, a photo of skin tags, and the words: HIGH SUGAR.

What Skin Says About Health

Knowing what to look for can mean the difference between life and death

A photo of male and female healthcare workers performing an endoscopy on a female patient.

Food Retention Risk Low for GLP-1 Users When Endoscopy Is Combined With Colonoscopy

Bowel preparation protocols appeared protective in small study

A photo of a stool collection container.

H. Pylori Testing Did Not Reduce Gastric Cancer Incidence, Mortality

Gastric cancer incidence was lower after adjusting for certain factors in post hoc analyses

FDA ODAC PD-(L)1 inhibitors over a computer rendering of esophageal cancer

No Benefit for PD-1 Inhibitors in Certain Gastroesophageal Cancers, FDA Panel Says

Despite problematic dataset, risk/benefit profile not favorable with PD-L1 expression below 1

A photo of a white tablet lying on top of many pink tablets.

Placebos Linked to Potential Harms in IBD Clinical Trials

Alternative designs needed, researchers caution

Timely Skin Cancer Screening After Organ Transplant Still Lacking

Only a minority of patients adhered to SUNTRAC screening recommendations

A computer rendering of monoclonal antibodies.

Novel Monoclonal Antibody Shows Promise in Ulcerative Colitis

26% of patients receiving tulisokibart achieved clinical remission vs 1% with placebo

FDA ODAC PD-(L)1 inhibitors over a computer rendering of esophageal cancer

Immunotherapy May Not Benefit All Gastroesophageal Cancer Patients, FDA Staff Says

Data since approvals suggest benefits limited to subgroups with PD-L1 expression of at least 1%

FDA CRL tradipitant (Vanda) over a computer rendering of a stomach.

FDA Rejects NK1R Antagonist for Gastroparesis

Drugmaker none-too-pleased with agency's request for additional studies

A close up photo of an injection pen.

GLP-1 Drugs in MASLD Tied to Lower Risk of Cirrhosis, Death

Limited benefit seen in patients with established cirrhosis, however

ESMO over a photo of Fira Barcelona Gran Via in Barcelona, Spain.

Another Possible Treatment Option for Intermediate-Stage Liver Cancer

Adding lenvatinib, pembrolizumab to TACE significantly improved PFS, numerically improved OS

FDA ADCOMM obeticholic acid (Ocaliva) over a computer rendering of a liver with the biliary tree highlighted.

Approved Liver Disease Drug Has No Clinical Benefit, FDA Panel Says

Agency advisors put their foot down on shaky science for Ocaliva in primary biliary cholangitis

A photo of surgeons performing a kidney transplant.

HHS Proposes Rule to Increase Access to Kidney, Liver Transplants in HIV Patients

Rule would streamline criteria for organ donation from donors with HIV to recipients with HIV

FDA WARNING fezolinetant (Veozah) over a photo of Veozah tablet, bottle and packaging.

FDA Warning on Hot Flash Drug

Clinicians should perform liver blood tests before and during Veozah treatment

FDA approved guselkumab (Tremfya) over a computer rendering of ulcerative colitis.

FDA Expands Approval of IL-23 Drug to Ulcerative Colitis

In trials, guselkumab more than doubled remission rates versus placebo

FDA ADCOMM obeticholic acid (Ocaliva) over a computer rendering of a liver with the biliary tree highlighted.

FDA Reviewers Skeptical of Ocaliva for Rare Bile Duct Disease

Agency advisory panel to examine complicated efficacy data and liver safety concerns

Thanks to Reddit, a New Diagnosis Is Bubbling Up Across the Nation

Botox can help "no-burp syndrome" symptoms

Comparing Fecal Immunochemical Tests; CVD Blood Test for Women

Also in TTHealthWatch: beta-blockers after MI

An xray image of the esophagus illuminated by a barium swallow.

Upper GI Damage Tied to Subsequent Parkinson's Disease

Mucosal damage seen on upper endoscopy associated with 76% higher Parkinson's risk

A computer rendering of monoclonal antibody treatment of ulcerative colitis.

Should Intensified Infliximab for Refractory Acute Severe UC Be Nixed?

PREDICT-UC trial found no benefit with intensified or accelerated regimens

A close up photo of a nurse adjusting the flow rate of an intravenous infusion.

Study Backs Skipping 5-FU Bolus in Chemo Regimens for Gastrointestinal Cancers

No difference in overall survival with versus without bolus, less toxicity without

A photo of surgeons performing a liver transplant.

Women With HCC Less Likely to Receive Liver Transplant, More Likely to Die Than Men

This difference is mostly explained by their smaller stature, researchers say

A photo of a radiologist monitoring a computer as a female nurse observes a patient during MRI.

The Higher the Disability Burden From Disease, the Higher the Suicide Risk

Having a medical condition was tied to increased risk of suicide in a dose-response-like manner

ESC over a photo of ExCeL London conference and exhibition center.

Novel Drug Reduced Triglycerides, Risk of Pancreatitis in Persistent Chylomicronemia

Benefits seen in patients with and without a genetic diagnosis

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